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Introduction: for readmission due to acute exacerbation,
enhancing the area under the receiver
Chronic obstructive pulmonary disease (COPD) operating characteristic curve (AUC) with a
involves persistent inflammation and oxidative sensitivity of 90% and a specificity of 93%.
stress Docosapentanoic acid (DPA) a
polyunsaturated fatty acid, and its hydroxylated Conclusion:
form, 7,17-hydroxydocosapentanoic acid (7,17
hydroxyDPA), are of interest due to their Our study highlights the significance of
potential anti-inflammatory and antioxidant Docosapentaenoic acid and its metabolite in
properties. The objective of this study was to enhancing our understanding of COPD and
assess the levels and roles of both compounds informing future treatment strategies.
in COPD and its association with the disease
severity
P12
Methods:
We conducted a case-control study in our THE SYNERGISTIC POTENTIAL OF
pulmonology department from March to DIAPHRAGMATIC ULTRASOUND
September 2022, including 40 male patients AND LIPOXIN EVALUATION IN
with confirmed, stable COPD. A control group COPD CARE
of 40 healthy smokers was also included.
Patients with other COPD-associated W. JELASSI1, A. HEDHLI1, K. EUCHI1, M. MJID1, Y. OUAHCHI1,
respiratory disea or receiving S. CHEIKHROUHOU1, S. TOUJANI1, B. DHAHRI1
immunosuppressive treatment were excluded. 1PULMONOLOGY DEPARTMENT, LA RABTA HOSPITAL, RL 18SP02,
Disease severity was assessed according to FACULTY OF MEDICINE OF TUNIS, TUNIS EL MANAR UNIVERSITY
the 2022 GOLD guidelines. Blood samples were - TUNIS (TUNISIA)
collected to measure DPA, 7,17-hydroxyDPA, and
C-reactive protein (CRP) levels. Additionally, Introduction :
forced spirometry was performed to evaluate Recent findings indicate that diaphragm
lung function. dysfunction is common in severe COPD patients
Results: and correlates with increased morbidity and
mortality. This weakness is believed to result
The mean age was 64 ± 8 years in the COPD from disuse associated with systemic
patients compared to 59 ± 7 years in the control inflammation, with lipoxins potentially
group. No significant differences were influencing both inflammatory processes and
observed in levels of DPA and 7,17-hydroxyDPA diaphragmatic function.
between the two groups. However, DPA levels The main objective of this study was to assess
were significantly lower in patients classified as the relationship between force reserve ratio
Group E according to the GOLD criteria (p = and lipoxins in patients with COPD
0.001). A statistically significant negative
correlation wa found between 7,17- Methods:
hydroxyDPA and Forced Expiratory Volume in
the first second (FEV1) (r = -0.434, p = 0.005). After We conducted a prospective study on 40
adjusting for age, comorbidities, and other consenting stable COPD patients according to
relevant parameters, lower levels of DPA and the GOLD 2023 guidelines at our pulmonology
7,17-hydroxyDPA acid were identified as department from October to December 2023.
independent risk factor for acute Patients with known or suspected co-
exacerbation o COPD. Notably, 7,17- morbidities affecting SPMs levels or respiratory
hydroxyDPA improved the predictive accuracy diseases related to COPD were excluded.
Blood samples for Lipoxins A4 and B4, 15-epi-
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